“I suppose what’s always speaking to me in the back of my mind is my mother,” says Benjamin Darbro. “She’s really the one who inspired this problem solving.” My question to University of Iowa professors John Manak, of the Department of Biology (College of Liberal Arts and Sciences) and Darbro, of the Stead Family Department of Pediatrics (Carver College of Medicine), was about the nature of their work. What is your relationship to complexity?